Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway

New chemotherapeutics are urgently required to control the tuberculosis pandemic. We describe a new pathway from trehalose to α-glucan in Mycobacterium tuberculosis comprising four enzymatic steps mediated by TreS, Pep2, GlgE (which has been identified as a maltosyltransferase that uses maltose 1-ph...

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Hlavní autoři: Kalscheuer, Rainer, Syson, Karl, Veeraraghavan, Usha, Weinrick, Brian, Biermann, Karolin E, Liu, Zhen, Sacchettini, James C, Besra, Gurdyal, Bornemann, Stephen, Jacobs, William R
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256575/
https://ncbi.nlm.nih.gov/pubmed/20305657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.340
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