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Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway
New chemotherapeutics are urgently required to control the tuberculosis pandemic. We describe a new pathway from trehalose to α-glucan in Mycobacterium tuberculosis comprising four enzymatic steps mediated by TreS, Pep2, GlgE (which has been identified as a maltosyltransferase that uses maltose 1-ph...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3256575/ https://ncbi.nlm.nih.gov/pubmed/20305657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.340 |
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