Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

L-Glutamine (Gln) functions physiologically to balance tissue requirements of carbon and nitrogen. It has been proposed that in cancer cells undergoing aerobic glycolysis, accelerated anabolism is sustained by Gln-derived carbons, which replenish the tricarboxylic acid (TCA) cycle (anaplerosis). How...

Full description

Saved in:
Bibliographic Details
Published in:Nat Cell Biol
Main Authors: Tardito, Saverio, Oudin, Anaïs, Ahmed, Shafiq U., Fack, Fred, Keunen, Olivier, Zheng, Liang, Miletic, Hrvoje, Sakariassen, Per Øystein, Weinstock, Adam, Wagner, Allon, Lindsay, Susan L., Hock, Andreas K., Barnett, Susan C., Ruppin, Eytan, Mørkve, Svein Harald, Lund-Johansen, Morten, Chalmers, Anthony J., Bjerkvig, Rolf, Niclou, Simone P., Gottlieb, Eyal
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663685/
https://ncbi.nlm.nih.gov/pubmed/26595383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3272
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items