Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy

The prevalence of depression and suicide is increased in patients with mesial temporal lobe epilepsy (MTLE); however, the underlying mechanism remains unknown. Anhedonia, a core symptom of depression that is predictive of suicide, is common in patients with MTLE. Glutamine synthetase, an astrocytic...

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Publicado en:Epilepsy Behav
Main Authors: Gruenbaum, Shaun E., Wang, Helen, Zaveri, Hitten P., Tang, Amber B., Lee, Tih-Shih W., Eid, Tore, Dhaher, Roni
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663049/
https://ncbi.nlm.nih.gov/pubmed/26262937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yebeh.2015.07.015
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