CaMKII-dependent myofilament Ca(2+) desensitization contributes to the frequency-dependent acceleration of relaxation

BACKGROUND: Previous studies suggest that CaMKII activity is required for frequency-dependent acceleration of relaxation (FDAR) in ventricular myocytes. We propose that the underlying mechanism involves CaMKII-dependent regulation of myofilament Ca(2+) sensitivity. METHODS AND RESULTS: Cardiac funct...

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Publicado en:Cell Calcium
Autores principales: Guilbert, Arnaud, Lim, Hyun Joung, Cheng, Jun, Wang, Yanggan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662934/
https://ncbi.nlm.nih.gov/pubmed/26297240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2015.08.001
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