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CaMKII inhibition in heart failure, beneficial, harmful, or both

Calmodulin-dependent protein kinase II (CaMKII) has been proposed to be a therapeutic target for heart failure (HF). However, the cardiac effect of chronic CaMKII inhibition in HF has not been well understood. We have tested alterations of Ca(2+) handling, excitation-contraction coupling, and in viv...

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Detalhes bibliográficos
Main Authors: Cheng, Jun, Xu, Lin, Lai, Dongwu, Guilbert, Arnaud, Lim, Hyun Joung, Keskanokwong, Thitima, Wang, Yanggan
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330794/
https://ncbi.nlm.nih.gov/pubmed/22287581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00812.2011
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