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CaMKII inhibition in heart failure, beneficial, harmful, or both
Calmodulin-dependent protein kinase II (CaMKII) has been proposed to be a therapeutic target for heart failure (HF). However, the cardiac effect of chronic CaMKII inhibition in HF has not been well understood. We have tested alterations of Ca(2+) handling, excitation-contraction coupling, and in viv...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Physiological Society
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3330794/ https://ncbi.nlm.nih.gov/pubmed/22287581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00812.2011 |
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