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DLL4/Notch1 and BMP9 interdependent signaling induces human endothelial cell quiescence via P27(KIP1) and thrombospondin-1

OBJECTIVE: BMP9/ALK1 and DLL4/Notch promote endothelial quiescence, and we aim to understand mechanistic interactions between the two pathways. We identify new targets that contribute to endothelial quiescence, and test whether loss of Dll4+/− in adult vasculature alters BMP signaling. APPROACH AND...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Rostama, Bahman, Turner, Jacqueline E., Seavey, Guy T., Norton, Christine R., Gridley, Thomas, Vary, Calvin P.H., Liaw, Lucy
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662626/
https://ncbi.nlm.nih.gov/pubmed/26471266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306541
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