RhoA mediated signaling in Notch-induced senescence like growth arrest and endothelial barrier dysfunction

OBJECTIVE: Notch signaling has a critical role in vascular development and morphogenesis. Activation of Notch in endothelial cells led to a senescence-like phenotype with loss of barrier function. Our objective was to understand the molecular pathways mediating this phenotype. METHODS AND RESULTS: H...

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Bibliografski detalji
Glavni autori: Venkatesh, Deepak, Fredette, Natalie, Rostama, Bahman, Tang, Yuefeng, Vary, Calvin P. H., Liaw, Lucy, Urs, Sumithra
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252819/
https://ncbi.nlm.nih.gov/pubmed/21273559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.221945
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