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RhoA mediated signaling in Notch-induced senescence like growth arrest and endothelial barrier dysfunction
OBJECTIVE: Notch signaling has a critical role in vascular development and morphogenesis. Activation of Notch in endothelial cells led to a senescence-like phenotype with loss of barrier function. Our objective was to understand the molecular pathways mediating this phenotype. METHODS AND RESULTS: H...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3252819/ https://ncbi.nlm.nih.gov/pubmed/21273559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.221945 |
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