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Therapeutic inhibition of miR-33 promotes fatty acid oxidation but does not ameliorate metabolic dysfunction in diet-induced obesity

OBJECTIVE: miR-33 has emerged as an important regulator of lipid homeostasis. Inhibition of miR-33 has been demonstrated as protective against atherosclerosis, however, recent studies in mice suggest that miR-33 inhibition may have adverse effects on lipid and insulin metabolism. Given the therapeut...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arterioscler Thromb Vasc Biol
Prif Awduron: Karunakaran, Denuja, Richards, Laura, Geoffrion, Michele, Barrette, Danyk, Gotfrit, Ryan J, Harper, Mary-Ellen, Rayner, Katey J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662623/
https://ncbi.nlm.nih.gov/pubmed/26427794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306404
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