A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches

Aristolochic acid I (AAI) is a plant alkaloid causing aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies. AAI is detoxified by cytochrome P450 (CYP)-mediated O-demethylation to 8-hydroxyaristolochic acid I (aristolochic acid Ia, AAIa). We previousl...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Stiborová, Marie, Bárta, František, Levová, Kateřina, Hodek, Petr, Schmeiser, Heinz H., Arlt, Volker M., Martínek, Václav
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661905/
https://ncbi.nlm.nih.gov/pubmed/26593908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms161126047
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