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Conservation and Role of Electrostatics in Thymidylate Synthase

Conservation of function across families of orthologous enzymes is generally accompanied by conservation of their active site electrostatic potentials. To study the electrostatic conservation in the highly conserved essential enzyme, thymidylate synthase (TS), we conducted a systematic species-based...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Garg, Divita, Skouloubris, Stephane, Briffotaux, Julien, Myllykallio, Hannu, Wade, Rebecca C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661567/
https://ncbi.nlm.nih.gov/pubmed/26612036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17356
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