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Conservation and Role of Electrostatics in Thymidylate Synthase

Conservation of function across families of orthologous enzymes is generally accompanied by conservation of their active site electrostatic potentials. To study the electrostatic conservation in the highly conserved essential enzyme, thymidylate synthase (TS), we conducted a systematic species-based...

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Pubblicato in:Sci Rep
Autori principali: Garg, Divita, Skouloubris, Stephane, Briffotaux, Julien, Myllykallio, Hannu, Wade, Rebecca C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661567/
https://ncbi.nlm.nih.gov/pubmed/26612036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17356
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