p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase

Phosphatidylinositol 3,4,5-trisphosphate (PIP(3))-dependent Rac exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase, facilitating the exchange of GDP for GTP on Rac1. GTP-bound Rac1 then activates its downstream effectors...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Barrows, Douglas, Schoenfeld, Sarah M., Hodakoski, Cindy, Silkov, Antonina, Honig, Barry, Couvillon, Anthony, Shymanets, Aliaksei, Nürnberg, Bernd, Asara, John M., Parsons, Ramon
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2015
Aiheet:
Signal Transduction
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661405/
https://ncbi.nlm.nih.gov/pubmed/26438819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668244
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia