An Integrated Approach for Analysis of the DNA Damage Response in Mammalian Cells: NUCLEOTIDE EXCISION REPAIR, DNA DAMAGE CHECKPOINT, AND APOPTOSIS

DNA damage by UV and UV-mimetic agents elicits a set of inter-related responses in mammalian cells, including DNA repair, DNA damage checkpoints, and apoptosis. Conventionally, these responses are analyzed separately using different methodologies. Here we describe a unified approach that is capable...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Choi, Jun-Hyuk, Kim, So-Young, Kim, Sook-Kyung, Kemp, Michael G., Sancar, Aziz
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661397/
https://ncbi.nlm.nih.gov/pubmed/26438822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.690354
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