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Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG)

Protein kinase G (PKG) is a major receptor of cGMP and controls signaling pathways often distinct from those regulated by cAMP. Hence, the selective activation of PKG by cGMP versus cAMP is critical. However, the mechanism of cGMP-versus-cAMP selectivity is only limitedly understood. Although the C-...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: VanSchouwen, Bryan, Selvaratnam, Rajeevan, Giri, Rajanish, Lorenz, Robin, Herberg, Friedrich W., Kim, Choel, Melacini, Giuseppe
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661378/
https://ncbi.nlm.nih.gov/pubmed/26370085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.685305
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