Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG)

Protein kinase G (PKG) is a major receptor of cGMP and controls signaling pathways often distinct from those regulated by cAMP. Hence, the selective activation of PKG by cGMP versus cAMP is critical. However, the mechanism of cGMP-versus-cAMP selectivity is only limitedly understood. Although the C-...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: VanSchouwen, Bryan, Selvaratnam, Rajeevan, Giri, Rajanish, Lorenz, Robin, Herberg, Friedrich W., Kim, Choel, Melacini, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661378/
https://ncbi.nlm.nih.gov/pubmed/26370085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.685305
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