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Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM

A current challenge in life sciences is to image cell membrane receptors while characterizing their specific interactions with various ligands. Addressing this issue has been hampered by the lack of suitable nanoscopic methods. Here we address this challenge and introduce multifunctional high-resolu...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Pfreundschuh, Moritz, Alsteens, David, Wieneke, Ralph, Zhang, Cheng, Coughlin, Shaun R., Tampé, Robert, Kobilka, Brian K., Müller, Daniel J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660198/
https://ncbi.nlm.nih.gov/pubmed/26561004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9857
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