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Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM

A current challenge in life sciences is to image cell membrane receptors while characterizing their specific interactions with various ligands. Addressing this issue has been hampered by the lack of suitable nanoscopic methods. Here we address this challenge and introduce multifunctional high-resolu...

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Detalles Bibliográficos
Publicado en:Nat Commun
Main Authors: Pfreundschuh, Moritz, Alsteens, David, Wieneke, Ralph, Zhang, Cheng, Coughlin, Shaun R., Tampé, Robert, Kobilka, Brian K., Müller, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660198/
https://ncbi.nlm.nih.gov/pubmed/26561004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9857
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