Control of Ligand-Binding Specificity Using Photocleavable Linkers in AFM Force Spectroscopy

[Image: see text] In recent decades, atomic force microscopy (AFM), in particular the force spectroscopy mode, has become a method of choice to study biomolecular interactions at the single-molecule level. However, grafting procedures as well as determining binding specificity remain challenging. We...

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Veröffentlicht in:Nano Lett
Hauptverfasser: Koehler, Melanie, Lo Giudice, Cristina, Vogl, Philipp, Ebner, Andreas, Hinterdorfer, Peter, Gruber, Hermann J., Alsteens, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7252943/
https://ncbi.nlm.nih.gov/pubmed/32320256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.0c01426
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