Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation

Linear ubiquitination is an atypical posttranslational modification catalyzed by the linear-ubiquitin-chain assembly complex (LUBAC), containing HOIP, HOIL-1L, and Sharpin. LUBAC facilitates NF-κB activation and inflammation upon receptor stimulation by ligating linear ubiquitin chains to critical s...

Full description

Saved in:
Bibliographic Details
Published in:mBio
Main Authors: Bowman, James, Rodgers, Mary A., Shi, Mude, Amatya, Rina, Hostager, Bruce, Iwai, Kazuhiro, Gao, Shou-Jiang, Jung, Jae U.
Format: Artigo
Language:Inglês
Published: American Society of Microbiology 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659476/
https://ncbi.nlm.nih.gov/pubmed/26578682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01777-15
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items