Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation

Linear ubiquitination is an atypical posttranslational modification catalyzed by the linear-ubiquitin-chain assembly complex (LUBAC), containing HOIP, HOIL-1L, and Sharpin. LUBAC facilitates NF-κB activation and inflammation upon receptor stimulation by ligating linear ubiquitin chains to critical s...

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Vydáno v:mBio
Hlavní autoři: Bowman, James, Rodgers, Mary A., Shi, Mude, Amatya, Rina, Hostager, Bruce, Iwai, Kazuhiro, Gao, Shou-Jiang, Jung, Jae U.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Microbiology 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659476/
https://ncbi.nlm.nih.gov/pubmed/26578682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01777-15
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