Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol–Bound β(1)-Adrenergic Receptor

Comparisons between structures of the β(1)-adrenergic receptor (AR) bound to either agonists, partial agonists, or weak partial agonists led to the proposal that rotamer changes of Ser(5.46), coupled to a contraction of the binding pocket, are sufficient to increase the probability of receptor activ...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Sato, Tomomi, Baker, Jillian, Warne, Tony, Brown, Giles A., Leslie, Andrew G.W., Congreve, Miles, Tate, Christopher G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658595/
https://ncbi.nlm.nih.gov/pubmed/26385885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.101030
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