Intramuscular Immunization of Mice with a Live-Attenuated Triple Mutant of Yersinia pestis CO92 Induces Robust Humoral and Cell-Mediated Immunity To Completely Protect Animals against Pneumonic Plague

Earlier, we showed that the Δlpp ΔmsbB Δail triple mutant of Yersinia pestis CO92 with deleted genes encoding Braun lipoprotein (Lpp), an acyltransferase (MsbB), and the attachment invasion locus (Ail), respectively, was avirulent in a mouse model of pneumonic plague. In this study, we further evalu...

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Publicado en:Clin Vaccine Immunol
Autores principales: Tiner, Bethany L., Sha, Jian, Ponnusamy, Duraisamy, Baze, Wallace B., Fitts, Eric C., Popov, Vsevolod L., van Lier, Christina J., Erova, Tatiana E., Chopra, Ashok K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Vaccines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658590/
https://ncbi.nlm.nih.gov/pubmed/26446423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00499-15
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