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Phosphorylation of the N-methyl-d-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal

Opioid withdrawal causes a dysphoric state that can lead to complications in pain patients and can propagate use in drug abusers and addicts. Opioid withdrawal changes the activity of neurons in the nucleus accumbens, an area rich in both opioid-binding mu opioid receptors and glutamate-binding NMDA...

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Bibliografske podrobnosti
izdano v:J Pharmacol Exp Ther
Main Authors: Anderson, Ethan M., Reeves, Turi, Kapernaros, Katherine, Neubert, John K., Caudle, Robert M.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658487/
https://ncbi.nlm.nih.gov/pubmed/26377910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.227629
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