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Orexin Mediates the Expression of Precipitated Morphine Withdrawal and Concurrent Activation of the Nucleus Accumbens Shell

BACKGROUND: The lateral hypothalamic neuropeptide, orexin (or hypocretin), is implicated in drug addiction. While a role for orexin has been shown in reward and dependence, the molecular and neural mechanisms are unclear. Here, we investigated the mechanism and neuroanatomical basis of orexin’s role...

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Detalhes bibliográficos
Main Authors: Sharf, Ruth, Sarhan, Maysa, DiLeone, Ralph J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529153/
https://ncbi.nlm.nih.gov/pubmed/18423425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2008.03.006
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