X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein

Lignende værker

• Novel Rapidly Diversifiable Antimicrobial RNA Polymerase Switch Region Inhibitors with Confirmed Mode of Action in Haemophilus influenzae
  af: Buurman, Ed T., et al.
  Udgivet: (2012)
• Minimalism and functionality: Structural lessons from the heterodimeric N4 bacteriophage RNA polymerase II
  af: Molodtsov, Vadim, et al.
  Udgivet: (2018)
• Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening
  af: Scharf, Nathan T., et al.
  Udgivet: (2016)
• Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis
  af: Molodtsov, Vadim, et al.
  Udgivet: (2017)
• X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway
  af: Murakami, Katsuhiko S., et al.
  Udgivet: (2017)