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Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening
Rifampin has been a cornerstone of tuberculosis (TB) treatment since its introduction. The rise of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB makes the development of novel therapeutics effective against these strains an urgent need. Site-specific mutations in the target enzym...
Tallennettuna:
| Julkaisussa: | SLAS Discov |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5323270/ https://ncbi.nlm.nih.gov/pubmed/28027449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555216679994 |
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