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Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening

Rifampin has been a cornerstone of tuberculosis (TB) treatment since its introduction. The rise of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB makes the development of novel therapeutics effective against these strains an urgent need. Site-specific mutations in the target enzym...

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Bibliografiska uppgifter
I publikationen:SLAS Discov
Huvudupphovsmän: Scharf, Nathan T., Molodtsov, Vadim, Kontos, Arrin, Murakami, Katsuhiko S., Garcia, George A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323270/
https://ncbi.nlm.nih.gov/pubmed/28027449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555216679994
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