Novel Rapidly Diversifiable Antimicrobial RNA Polymerase Switch Region Inhibitors with Confirmed Mode of Action in Haemophilus influenzae

A series of inhibitors with a squaramide core was synthesized following its discovery in a high-throughput screen for novel inhibitors of a transcription-coupled translation assay using Escherichia coli S30 extracts. The inhibitors were inactive when the plasmid substrate was replaced with mRNA, sug...

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Autori principali: Buurman, Ed T., Foulk, Melinda A., Gao, Ning, Laganas, Valerie A., McKinney, David C., Moustakas, Demetri T., Rose, Jonathan A., Shapiro, Adam B., Fleming, Paul R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458661/
https://ncbi.nlm.nih.gov/pubmed/22843845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01103-12
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