Structural determinant for switching between the polymerase and exonuclease modes in the PCNA-replicative DNA polymerase complex

Proliferating cell nuclear antigen (PCNA) is responsible for the processivity of DNA polymerase. We determined the crystal structure of Pyrococcus furiosus DNA polymerase (PfuPol) complexed with the cognate monomeric PCNA, which allowed us to construct a convincing model of the polymerase-PCNA ring...

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Detaylı Bibliyografya
Asıl Yazarlar: Nishida, Hirokazu, Mayanagi, Kouta, Kiyonari, Shinichi, Sato, Yuichi, Oyama, Takuji, Ishino, Yoshizumi, Morikawa, Kosuke
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791594/
https://ncbi.nlm.nih.gov/pubmed/19934045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907780106
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