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Structural determinant for switching between the polymerase and exonuclease modes in the PCNA-replicative DNA polymerase complex
Proliferating cell nuclear antigen (PCNA) is responsible for the processivity of DNA polymerase. We determined the crystal structure of Pyrococcus furiosus DNA polymerase (PfuPol) complexed with the cognate monomeric PCNA, which allowed us to construct a convincing model of the polymerase-PCNA ring...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2791594/ https://ncbi.nlm.nih.gov/pubmed/19934045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907780106 |
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