The Role of a Novel Auxiliary Pocket in Bacterial Phenylalanyl-tRNA Synthetase Druggability

The antimicrobial activity of phenyl-thiazolylurea-sulfonamides against Staphylococcus aureus PheRS are dependent upon phenylalanine levels in the extracellular fluids. Inhibitor efficacy in animal models of infection is substantially diminished by dietary phenylalanine intake, thereby reducing the...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Abibi, Ayome, Ferguson, Andrew D., Fleming, Paul R., Gao, Ning, Hajec, Laurel I., Hu, Jun, Laganas, Valerie A., McKinney, David C., McLeod, Sarah M., Prince, D. Bryan, Shapiro, Adam B., Buurman, Ed T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118124/
https://ncbi.nlm.nih.gov/pubmed/24936059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.574061
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados