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Druggable Transient Pockets in Protein Kinases
Drug discovery using small molecule inhibitors is reaching a stalemate due to low selectivity, adverse off-target effects and inevitable failures in clinical trials. Conventional chemical screening methods may miss potent small molecules because of their use of simple but outdated kits composed of r...
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| Publicado no: | Molecules |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7865889/ https://ncbi.nlm.nih.gov/pubmed/33513739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26030651 |
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