The Role of a Novel Auxiliary Pocket in Bacterial Phenylalanyl-tRNA Synthetase Druggability

The antimicrobial activity of phenyl-thiazolylurea-sulfonamides against Staphylococcus aureus PheRS are dependent upon phenylalanine levels in the extracellular fluids. Inhibitor efficacy in animal models of infection is substantially diminished by dietary phenylalanine intake, thereby reducing the...

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Bibliografiske detaljer
Main Authors: Abibi, Ayome, Ferguson, Andrew D., Fleming, Paul R., Gao, Ning, Hajec, Laurel I., Hu, Jun, Laganas, Valerie A., McKinney, David C., McLeod, Sarah M., Prince, D. Bryan, Shapiro, Adam B., Buurman, Ed T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Protein Synthesis and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118124/
https://ncbi.nlm.nih.gov/pubmed/24936059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.574061
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