T lymphocytes need less than 3 min to discriminate between peptide MHCs with similar TCR-binding parameters

T lymphocytes need to detect rare cognate foreign peptides among numerous foreign and self-peptides. This discrimination seems to be based on the kinetics of TCRs binding to their peptide–MHC (pMHC) ligands, but there is little direct information on the minimum time required for processing elementar...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Eur J Immunol
Egile Nagusiak: Brodovitch, Alexandre, Shenderov, Eugene, Cerundolo, Vincenzo, Bongrand, Pierre, Pierres, Anne, van der Merwe, Philip Anton
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley & Sons, Ltd 2015
Gaiak:
Cellular Immune Response
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657482/
https://ncbi.nlm.nih.gov/pubmed/25782169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201445214
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