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T lymphocytes need less than 3 min to discriminate between peptide MHCs with similar TCR-binding parameters
T lymphocytes need to detect rare cognate foreign peptides among numerous foreign and self-peptides. This discrimination seems to be based on the kinetics of TCRs binding to their peptide–MHC (pMHC) ligands, but there is little direct information on the minimum time required for processing elementar...
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| Publicado no: | Eur J Immunol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4657482/ https://ncbi.nlm.nih.gov/pubmed/25782169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201445214 |
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