The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells

The cell fate determinant Numb orchestrates tissue morphogenesis and patterning in developmental systems. In the human mammary gland, Numb is a tumor suppressor and regulates p53 levels. However, whether this function is linked to its role in fate determination remains unclear. Here, by exploiting a...

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Publicat a:J Cell Biol
Autors principals: Tosoni, Daniela, Zecchini, Silvia, Coazzoli, Marco, Colaluca, Ivan, Mazzarol, Giovanni, Rubio, Alicia, Caccia, Michele, Villa, Emanuele, Zilian, Olav, Di Fiore, Pier Paolo, Pece, Salvatore
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657167/
https://ncbi.nlm.nih.gov/pubmed/26598619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201505037
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