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Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
The biological antagonism between Notch and Numb controls the proliferative/differentiative balance in development and homeostasis. Although altered Notch signaling has been linked to human diseases, including cancer, evidence for a substantial involvement of Notch in human tumors has remained elusi...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2004
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172557/ https://ncbi.nlm.nih.gov/pubmed/15492044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200406140 |
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