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Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancers
The cell fate determinant Numb is frequently downregulated in human breast cancers (BCs), resulting in p53 inactivation and an aggressive disease course. In the mouse mammary gland, Numb/p53 downregulation leads to aberrant tissue morphogenesis, expansion of the stem cell compartment, and emergence...
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| 出版年: | EMBO Mol Med |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5412856/ https://ncbi.nlm.nih.gov/pubmed/28298340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606940 |
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