Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancers

The cell fate determinant Numb is frequently downregulated in human breast cancers (BCs), resulting in p53 inactivation and an aggressive disease course. In the mouse mammary gland, Numb/p53 downregulation leads to aberrant tissue morphogenesis, expansion of the stem cell compartment, and emergence...

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Publicado en:EMBO Mol Med
Autores principales: Tosoni, Daniela, Pambianco, Sarah, Ekalle Soppo, Blanche, Zecchini, Silvia, Bertalot, Giovanni, Pruneri, Giancarlo, Viale, Giuseppe, Di Fiore, Pier Paolo, Pece, Salvatore
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412856/
https://ncbi.nlm.nih.gov/pubmed/28298340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606940
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