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Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancers

The cell fate determinant Numb is frequently downregulated in human breast cancers (BCs), resulting in p53 inactivation and an aggressive disease course. In the mouse mammary gland, Numb/p53 downregulation leads to aberrant tissue morphogenesis, expansion of the stem cell compartment, and emergence...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Tosoni, Daniela, Pambianco, Sarah, Ekalle Soppo, Blanche, Zecchini, Silvia, Bertalot, Giovanni, Pruneri, Giancarlo, Viale, Giuseppe, Di Fiore, Pier Paolo, Pece, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412856/
https://ncbi.nlm.nih.gov/pubmed/28298340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606940
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