Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancers

The cell fate determinant Numb is frequently downregulated in human breast cancers (BCs), resulting in p53 inactivation and an aggressive disease course. In the mouse mammary gland, Numb/p53 downregulation leads to aberrant tissue morphogenesis, expansion of the stem cell compartment, and emergence...

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Bibliographic Details
Published in:EMBO Mol Med
Main Authors: Tosoni, Daniela, Pambianco, Sarah, Ekalle Soppo, Blanche, Zecchini, Silvia, Bertalot, Giovanni, Pruneri, Giancarlo, Viale, Giuseppe, Di Fiore, Pier Paolo, Pece, Salvatore
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412856/
https://ncbi.nlm.nih.gov/pubmed/28298340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606940
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