Loading...

Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancers

The cell fate determinant Numb is frequently downregulated in human breast cancers (BCs), resulting in p53 inactivation and an aggressive disease course. In the mouse mammary gland, Numb/p53 downregulation leads to aberrant tissue morphogenesis, expansion of the stem cell compartment, and emergence...

Full description

Saved in:
Bibliographic Details
Published in:EMBO Mol Med
Main Authors: Tosoni, Daniela, Pambianco, Sarah, Ekalle Soppo, Blanche, Zecchini, Silvia, Bertalot, Giovanni, Pruneri, Giancarlo, Viale, Giuseppe, Di Fiore, Pier Paolo, Pece, Salvatore
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412856/
https://ncbi.nlm.nih.gov/pubmed/28298340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606940
Tags: Add Tag
No Tags, Be the first to tag this record!