Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancers

The cell fate determinant Numb is frequently downregulated in human breast cancers (BCs), resulting in p53 inactivation and an aggressive disease course. In the mouse mammary gland, Numb/p53 downregulation leads to aberrant tissue morphogenesis, expansion of the stem cell compartment, and emergence...

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Dades bibliogràfiques
Publicat a:EMBO Mol Med
Autors principals: Tosoni, Daniela, Pambianco, Sarah, Ekalle Soppo, Blanche, Zecchini, Silvia, Bertalot, Giovanni, Pruneri, Giancarlo, Viale, Giuseppe, Di Fiore, Pier Paolo, Pece, Salvatore
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412856/
https://ncbi.nlm.nih.gov/pubmed/28298340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606940
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