A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer

Numb functions as an oncosuppressor by inhibiting Notch signaling and stabilizing p53. This latter effect depends on the interaction of Numb with Mdm2, the E3 ligase that ubiquitinates p53 and commits it to degradation. In breast cancer (BC), loss of Numb results in a reduction of p53-mediated respo...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Colaluca, Ivan Nicola, Basile, Andrea, Freiburger, Lee, D'Uva, Veronica, Disalvatore, Davide, Vecchi, Manuela, Confalonieri, Stefano, Tosoni, Daniela, Cecatiello, Valentina, Malabarba, Maria Grazia, Yang, Chun-Jiun, Kainosho, Masatsune, Sattler, Michael, Mapelli, Marina, Pece, Salvatore, Di Fiore, Pier Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2018
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800818/
https://ncbi.nlm.nih.gov/pubmed/29269425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201709092
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