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A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer
Numb functions as an oncosuppressor by inhibiting Notch signaling and stabilizing p53. This latter effect depends on the interaction of Numb with Mdm2, the E3 ligase that ubiquitinates p53 and commits it to degradation. In breast cancer (BC), loss of Numb results in a reduction of p53-mediated respo...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5800818/ https://ncbi.nlm.nih.gov/pubmed/29269425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201709092 |
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