Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus

Folate receptor (FR)-β has been identified as a promising target for antimacrophage and antiinflammatory therapies. In the present study, we investigated EC0565, a folic acid–derivative of everolimus, as a FR-specific inhibitor of the mammalian target of rapamycin (mTOR). Because of its amphiphilic...

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Veröffentlicht in:Mol Med
Hauptverfasser: Lu, Yingjuan, Parker, Nikki, Kleindl, Paul J, Cross, Vicky A, Wollak, Kristin, Westrick, Elaine, Stinnette, Torian W, Gehrke, Mark A, Wang, Kevin, Santhapuram, Hari Krishna R, You, Fei, Hahn, Spencer J, Vaughn, Jeremy F, Klein, Patrick J, Vlahov, Iontcho R, Low, Philip S, Leamon, Christopher P
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Feinstein Institute Press 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656201/
https://ncbi.nlm.nih.gov/pubmed/26181632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00040
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