Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus

Folate receptor (FR)-β has been identified as a promising target for antimacrophage and antiinflammatory therapies. In the present study, we investigated EC0565, a folic acid–derivative of everolimus, as a FR-specific inhibitor of the mammalian target of rapamycin (mTOR). Because of its amphiphilic...

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Publicado no:Mol Med
Main Authors: Lu, Yingjuan, Parker, Nikki, Kleindl, Paul J, Cross, Vicky A, Wollak, Kristin, Westrick, Elaine, Stinnette, Torian W, Gehrke, Mark A, Wang, Kevin, Santhapuram, Hari Krishna R, You, Fei, Hahn, Spencer J, Vaughn, Jeremy F, Klein, Patrick J, Vlahov, Iontcho R, Low, Philip S, Leamon, Christopher P
Formato: Artigo
Idioma:Inglês
Publicado em: The Feinstein Institute Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656201/
https://ncbi.nlm.nih.gov/pubmed/26181632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00040
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