Mechanistic insights into Lp(a)-induced IL-8 expression: a role for oxidized phospholipid modification of apo(a)

Elevated lipoprotein (a) [Lp(a)] levels are a causal risk factor for coronary heart disease. Accumulating evidence suggests that Lp(a) can stimulate cellular inflammatory responses through the kringle-containing apolipoprotein (a) [apo(a)] component. Here, we report that recombinant apo(a) containin...

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Publicat a:J Lipid Res
Autors principals: Scipione, Corey A., Sayegh, Sera E., Romagnuolo, Rocco, Tsimikas, Sotirios, Marcovina, Santica M., Boffa, Michael B., Koschinsky, Marlys L.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655984/
https://ncbi.nlm.nih.gov/pubmed/26474593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M060210
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