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Inhibition of plasminogen activation by apo(a): role of carboxyl-terminal lysines and identification of inhibitory domains in apo(a)

Apo(a), the distinguishing protein component of lipoprotein(a) [Lp(a)], exhibits sequence similarity to plasminogen and can inhibit binding of plasminogen to cell surfaces. Plasmin generated on the surface of vascular cells plays a role in cell migration and proliferation, two of the fibroproliferat...

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Detalhes bibliográficos
Main Authors: Romagnuolo, Rocco, Marcovina, Santica M., Boffa, Michael B., Koschinsky, Marlys L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966697/
https://ncbi.nlm.nih.gov/pubmed/24478033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M036566
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