Lipoprotein(a) Catabolism Is Regulated by Proprotein Convertase Subtilisin/Kexin Type 9 through the Low Density Lipoprotein Receptor

Elevated levels of lipoprotein(a) (Lp(a)) have been identified as an independent risk factor for coronary heart disease. Plasma Lp(a) levels are reduced by monoclonal antibodies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9). However, the mechanism of Lp(a) catabolism in vivo and th...

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Udgivet i:J Biol Chem
Main Authors: Romagnuolo, Rocco, Scipione, Corey A., Boffa, Michael B., Marcovina, Santica M., Seidah, Nabil G., Koschinsky, Marlys L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Lipids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416867/
https://ncbi.nlm.nih.gov/pubmed/25778403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611988
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