Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease

Chronic exposure to elevated levels of glucocorticoids has been linked to age-related cognitive decline and may play a role in Alzheimer's disease. In the brain, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies intracellular glucocorticoid levels. We show that short-term treatment o...

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Vydáno v:Endocrinology
Hlavní autoři: Sooy, Karen, Noble, June, McBride, Andrew, Binnie, Margaret, Yau, Joyce L. W., Seckl, Jonathan R., Walker, Brian R., Webster, Scott P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2015
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655221/
https://ncbi.nlm.nih.gov/pubmed/26305888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1395
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