Activation-induced cytidine deaminase (AID) expression in human B-cell precursors is essential for central B-cell tolerance

Activation-induced cytidine deaminase (AID), the enzyme mediating class switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin genes, is essential for the removal of developing autoreactive B cells. How AID mediates central B-cell tolerance remains unknown. We report that AID e...

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Enregistré dans:
Détails bibliographiques
Publié dans:Immunity
Auteurs principaux: Cantaert, Tineke, Schickel, Jean-Nicolas, Bannock, Jason M., Ng, Yen-Shing, Massad, Christopher, Oe, Tyler, Wu, Renee, Lavoie, Aubert, Walter, Jolan E., Notarangelo, Luigi D., Al-Herz, Waleed, Kilic, Sara Sebnem, Ochs, Hans D., Nonoyama, Shigeaki, Durandy, Anne, Meffre, Eric
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654975/
https://ncbi.nlm.nih.gov/pubmed/26546282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.10.002
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