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Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint
Patients with mutations in AICDA, which encodes activation-induced cytidine deaminase (AID), display an impaired peripheral B cell tolerance. AID mediates class-switch recombination (CSR) and somatic hypermutation (SHM) in B cells, but the mechanism by which AID prevents the accumulation of autoreac...
Sparad:
I publikationen: | J Clin Invest |
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Huvudupphovsmän: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
Materialtyp: | Artigo |
Språk: | Inglês |
Publicerad: |
American Society for Clinical Investigation
2016
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Ämnen: | |
Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5096912/ https://ncbi.nlm.nih.gov/pubmed/27701145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84645 |
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