Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint

Patients with mutations in AICDA, which encodes activation-induced cytidine deaminase (AID), display an impaired peripheral B cell tolerance. AID mediates class-switch recombination (CSR) and somatic hypermutation (SHM) in B cells, but the mechanism by which AID prevents the accumulation of autoreac...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Cantaert, Tineke, Schickel, Jean-Nicolas, Bannock, Jason M., Ng, Yen-Shing, Massad, Christopher, Delmotte, Fabien R., Yamakawa, Natsuko, Glauzy, Salome, Chamberlain, Nicolas, Kinnunen, Tuure, Menard, Laurence, Lavoie, Aubert, Walter, Jolan E., Notarangelo, Luigi D., Bruneau, Julie, Al-Herz, Waleed, Kilic, Sara Sebnem, Ochs, Hans D., Cunningham-Rundles, Charlotte, van der Burg, Mirjam, Kuijpers, Taco W., Kracker, Sven, Kaneko, Hideo, Sekinaka, Yujin, Nonoyama, Shigeaki, Durandy, Anne, Meffre, Eric
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096912/
https://ncbi.nlm.nih.gov/pubmed/27701145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84645
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