Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans

Impaired immune functions leading to primary immunodeficiencies often correlate with paradoxical autoimmune complications; patients with hyper-IgM syndromes who are deficient in activation-induced cytidine deaminase (AID), which is required for class-switch recombination and somatic hypermutation, a...

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Dades bibliogràfiques
Autors principals: Meyers, Greta, Ng, Yen-Shing, Bannock, Jason M., Lavoie, Aubert, Walter, Jolan E., Notarangelo, Luigi D., Kilic, Sara S., Aksu, Guzide, Debré, Marianne, Rieux-Laucat, Frédéric, Conley, Mary Ellen, Cunningham-Rundles, Charlotte, Durandy, Anne, Meffre, Eric
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136251/
https://ncbi.nlm.nih.gov/pubmed/21700883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102600108
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