Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)

Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or two physiological enzymatic activities differentially regulated by cytochrome b5. How this is achie...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Simonov, Alexandr N., Holien, Jessica K., Yeung, Joyee Chun In, Nguyen, Ann D., Corbin, C. Jo, Zheng, Jie, Kuznetsov, Vladimir L., Auchus, Richard J., Conley, Alan J., Bond, Alan M., Parker, Michael W., Rodgers, Raymond J., Martin, Lisandra L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654539/
https://ncbi.nlm.nih.gov/pubmed/26587646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141252
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