Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)

Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or two physiological enzymatic activities differentially regulated by cytochrome b5. How this is achie...

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Udgivet i:PLoS One
Main Authors: Simonov, Alexandr N., Holien, Jessica K., Yeung, Joyee Chun In, Nguyen, Ann D., Corbin, C. Jo, Zheng, Jie, Kuznetsov, Vladimir L., Auchus, Richard J., Conley, Alan J., Bond, Alan M., Parker, Michael W., Rodgers, Raymond J., Martin, Lisandra L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654539/
https://ncbi.nlm.nih.gov/pubmed/26587646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141252
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