Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling

BACKGROUND: Colorectal cancer is the third most common malignancy in humans and novel therapeutic approaches are urgently needed. Autophagy is an evolutionarily highly conserved cellular process by which cells collect unnecessary organelles or misfolded proteins and subsequently degrade them in vesi...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Koehler, Bruno Christian, Jassowicz, Adam, Scherr, Anna-Lena, Lorenz, Stephan, Radhakrishnan, Praveen, Kautz, Nicole, Elssner, Christin, Weiss, Johanna, Jaeger, Dirk, Schneider, Martin, Schulze-Bergkamen, Henning
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653869/
https://ncbi.nlm.nih.gov/pubmed/26585594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1929-y
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