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The novel mechanism of lenalidomide activity
Lenalidomide acts by a novel drug mechanism—modulation of the substrate specificity of the CRL4(CRBN) E3 ubiquitin ligase. In multiple myeloma, lenalidomide induces the ubiquitination of IKZF1 and IKZF3 by CRL4(CRBN). Subsequent proteasomal degradation of these transcription factors kills multiple m...
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| Publicado no: | Blood |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4653765/ https://ncbi.nlm.nih.gov/pubmed/26438514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-567958 |
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